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Yes, there is a difference in usage between 毒 (du2) and 毒药 (du2yao4).
- 毒 (du2) refers to poison in general, including both natural and man-made substances that can cause harm or death when ingested, inhaled, or absorbed.
- 毒药 (du2yao4) specifically refers to a poisonous substance that is used as a drug or medicine, often for the purpose of killing or harming someone.
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In everyday conversation, the word '毒' (du2) is commonly used to refer to something that is poisonous or toxic. It can also be used to describe a person or situation that is harmful or dangerous, often with a negative connotation.
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